Mycobacterium tuberculosis–Induced Apoptosis in Monocytes/Macrophages: Early Membrane Modifications and Intracellular Mycobacterial Viability

Mycobacterium tuberculosis Intracellular Macrophages Reduces the Viability of Fas Ligand-Induced Apoptosis of Infected Human

Phagosomal processing of Mycobacterium tuberculosis antigen 85B is modulated independently of mycobacterial viability and phagosome maturation.

Control of Mycobacterium tuberculosis infection requires CD4 T-cell responses and major histocompatibility complex class II (MHC-II) processing of M. tuberculosis antigens (Ags). We have previously demonstrated that macrophages process heat-killed (HK) M. tuberculosis more efficiently than live M. tuberculosis. These observations suggested that live M. tuberculosis may inhibit Ag processing by ...

Extracellular Vesicles Released from Mycobacterium tuberculosis-Infected Neutrophils Promote Macrophage Autophagy and Decrease Intracellular Mycobacterial Survival

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis (Mtb). In the lungs, macrophages and neutrophils are the first immune cells that have contact with the infecting mycobacteria. Neutrophils are phagocytic cells that kill microorganisms through several mechanisms, which include the lytic enzymes and antimicrobial peptides that are found in their lysosomes, and the product...

Effect of Ghrelin on Viability, Proliferation, and Apoptosis in Human Granulosa Cells, In Vitro

Background and Objectives: Ghrelin is a peptide hormone that was initially derived from stomach and introduced as an endogenous ligand for the growth hormone secretagogue receptor. Ghrelin is fundamentally involved in regulation of nutrition and energy homeostasis in the body. It has been shown that ghrelin has an important role in fertility in women. The purpose of the present study was to ass...

I-33: Early Assessment of Pregnancy Viability

Early determination of pregnancy viability is essential for women at risk for experiencing ectopic pregnancy or spontaneous abortion. Several markers of pregnancy viability have been identified including serial human chorionic gonadotropin (hCG) monitoring and sonography, in addition to several less commonly available biochemical markers. An ideal test would be readily available, inexpensive an...